Active diabetic foot disease relates to problems associated with peripheral arterial disease (PAD), infection and/or neuropathy. Diabetes still remains one of the main causes of non-traumatic limb amputation and premature death, both of which may be preventable (Prompers et al, 2007; National Institute for Health and Care Excellence [NICE], 2019). The purpose of this article is to discuss three of the clinical emergencies seen in the diabetic foot, namely PAD, infection and Charcot neuro-osteoarthropathy (Charcot foot). The aim is to provide a refresher of diabetes and the associated complications and to enhance knowledge and clinical skills in the management of diabetic foot disease. A case report is used to provide narrative to the potential complexity seen within the process.